Title: Associate Professor
E-mail: [email protected]
Lattes: http://lattes.cnpq.br/2947608523407021
Orcid: ID  0000-0003-1999-9478 – https://orcid.org/0000-0003-1999-9478
Scopus: ID 13611559300 – https://www.scopus.com/authid/detail.uri?authorId=13611559300
Google scholar: ID A39yDVgAAAAJ – https://scholar.google.com.br/citations?user=A39yDVgAAAAJ&hl=pt-BR&oi=ao
Research ID: D-2975-2009 – https://publons.com/researcher/2854597/marco-k-demange/

Line of Research:

Orthobiologics and cell therapy in the treatment of musculoskeletal system problems

Our main line of research involves orthobiologics and cell therapy in the treatment of problems of the musculoskeletal system. Additionally, there is a focus on treatment of knee joint injuries. In this line, there is an emphasis on treatment of injuries to the articular cartilage, ligament injuries, joint instabilities and degenerative processes of the knee. In this line of research, we highlight the study of the osteochondral unit, the subchondral bone and its interaction with joint cartilage injury. We also highlight studies related to cell therapy with emphasis on chondrocytes and mesenchymal stem cells. Thus, the objective is the study of methods to delay the evolution of joint injuries, control pain, accelerate the repair process and/or promote joint regeneration.

Relevant articles:

  1. Titan A, Schär M, Hutchinson I, Demange M, Chen T, Rodeo S. Growth Factor Delivery to a Cartilage-Cartilage Interface Using Platelet-Rich Concentrates on a Hyaluronic Acid Scaffold. Arthroscopy. 2020 May;36(5):1431-40. doi:10.1016/j.arthro.2019.12.004.
  2. Demange MK, Minas T, von Keudell A, Sodha S, Bryant T, Gomoll AH.Intralesional Osteophyte Regrowth Following Autologous Chondrocyte Implantation after Previous Treatment with Marrow Stimulation Technique. Cartilage. 2017Apr;8(2)131-8. doi: 10.1177/1947603516653208.
  3. de Almeida AM, Demange MK, Sobrado MF, Rodrigues MB, Pedrinelli A, Hernandez AJ. Patellar tendon healing with platelet-rich plasma: a prospective randomized controlled trial. Am J Sports Med. 2012 Jun;40(6):1282-8. doi: 10.1177/0363546512441344.
  4. Bonadio MB, Giglio PN, Helito CP, Pécora JR, Camanho GL, Demange MK. Subchondroplasty for treating bone marrow lesions in the knee – initial experience. Rev Bras Ortop. 2017 Apr 28;52(3):325-30. doi:10.1016/j.rboe.2017.04.003.
  5. Tírico LE, Demange MK, Santos LA, de Rezende MU, Helito CP, Gobbi RG, Pécora JR, Croci AT, Bugbee WD. Development of a Fresh Osteochondral Allograft Program Outside North America. Cartilage. 2016 Jul;7(3):222-8. doi: 10.1177/1947603515618484.

 

PROJETOS ORIENTADOR/ LINHA

Linha 2. DESENVOLVIMENTO DE ENSAIOS E MODELOS PARA SUBSTITUIÇÃO ARTICULAR E INSTABILIDADE ARTICULARES
PROJETO MARCO DEMANGE: ESTUDOS DE ARTROPLASTIAS DE SUBSTITUIÇÃO ARTICULAR DO JOELHO
Linha 4. OSTEOIMUNOLOGIA E AVALIAÇÃO DOS PROCESSOS DE REGENERAÇÃO MÚSCULOESQUELÉTICA
PROJETO MARCO DEMANGE: ESTUDOS DE ORTOBIOLÓGICOS E CÉLULAS TRONCO NO TRATAMENTO DE LESÕES ARTICULARES DO JOELHO
PROJETO MARCO DEMANGE: ESTUDOS DO USO DE OXIGENIOTERAPIA HIPERBÁRICA NAS LESÕES DO SISTEMA MUSCULOESQUELÉTICO
Linha 5. MODELOS CLÍNICOS E EXPERIMENTAIS DA ANÁLISE FUNCIONAL DO MOVIMENTO HUMANO
PROJETO MARCO DEMANGE: ESTUDO DAS LESÕES LIGAMENTARES DO JOELHO